Clinical Impact of Mixed Respiratory Viral Infection in Children with Adenoviral Infection

Lee, Hyun Jun; Seo, Young Eun; Han, Seung Beom; Jeong, Dae Chul; Kang, Jin Han

Respiratory viral coinfection in ADV infection may cause prolonged hospitalization with or without increase in disease severity, represented by oxygen supplementation and ICU admission [17, 20, 21] . Some other investigators have, on the other hand, reported no significant effect of coinfection on the duration of hospitalization and disease severity [18, 22] . In the present study, coinfection caused more LRTIs compared with ADV single infection, and therefore, manifested as more clinically severe and progressive disease than ADV single infection. In addition, oxygen therapy was administered more frequently in the coinfection group, especially in children coinfected with ADV and RSV, than in the ADV group. However, the oxygen supplementation duration in the coinfection group was less than 3 days, and there was no ICU admission and mortality in this group. Furthermore, the duration of hospitalization and fever was not significantly different between the coinfection and ADV groups. This suggested that even as respiratory viral coinfection may contribute to increased disease severity in children with ADV infection, appropriate treatment for such a condition can prevent further disease progression and poor prognosis.