Selected article for: "functional significance and molecular mechanism"
Author: Lew, Qiao Jing; Chu, Kai Ling; Lee, Jialing; Koh, Poh Ling; Rajasegaran, Vikneswari; Teo, Jin Yuan; Chao, Sheng-Hao
Title: PCAF interacts with XBP-1S and mediates XBP-1S-dependent transcription
  • Document date: 2010_9_4
    • ID: 174q2pjw_3
    Snippet: The localization of a transactivation domain within the C-terminus of XBP-1S helps to explain the transactivating ability of XBP-1S. However, the molecular mechanism of XBP-1S transactivation still remains to be determined. One possibility is that the C-terminus of XBP-1S may interact with a specific cellular co-activator, which is responsible for the up-regulation of XBP-1S target genes. Here, we identify a histone acetyltransferase (HAT), p300/.....
    Document: The localization of a transactivation domain within the C-terminus of XBP-1S helps to explain the transactivating ability of XBP-1S. However, the molecular mechanism of XBP-1S transactivation still remains to be determined. One possibility is that the C-terminus of XBP-1S may interact with a specific cellular co-activator, which is responsible for the up-regulation of XBP-1S target genes. Here, we identify a histone acetyltransferase (HAT), p300/CBP-associated factor (PCAF), as a XBP-1Sspecific binding protein and demonstrate the functional significance of the PCAF-XBP-1S interaction in the XBP-1S-mediated transcription.

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