Selected article for: "DENV infection and primary DENV infection severity"
Author: Avirutnan, Panisadee; Hauhart, Richard E.; Marovich, Mary A.; Garred, Peter; Atkinson, John P.; Diamond, Michael S.
Title: Complement-Mediated Neutralization of Dengue Virus Requires Mannose-Binding Lectin
  • Document date: 2011_12_13
    • ID: 1x3n5job_25
    Snippet: Overall, our studies support the hypothesis that MBL contributes to protection against DENV infection. The interplay between allelic variations of MBL, the specific viral serotypes, and the type of infection (primary versus secondary) could impact the severity of DENV infection. Further prospective clinical studies are warranted to investigate the precise role of MBL deficiency and its effects on DENV infection in humans......
    Document: Overall, our studies support the hypothesis that MBL contributes to protection against DENV infection. The interplay between allelic variations of MBL, the specific viral serotypes, and the type of infection (primary versus secondary) could impact the severity of DENV infection. Further prospective clinical studies are warranted to investigate the precise role of MBL deficiency and its effects on DENV infection in humans.

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