Author: GASPARINI, R.; AMICIZIA, D.; LAI, PL.; BRAGAZZI, NL.; PANATTO, D.
Title: Compounds with anti-influenza activity: present and future of strategies for the optimal treatment and management of influenza. Part I: influenza life-cycle and currently available drugs Document date: 2014_9_23
ID: 5td3lhlf_23
Snippet: After being translated, proteins are transported to the Golgi network, where they are modified. Modifications, such as glycosylation of HA and NA, palmitoylation/Sacylation of HA and M2, phosphorylation of NS1, and SUMOylation of M1, NS1, NP, PB1 and NEP by SU-MO-1/2/3 (Small Ubiquitin-like Modifier type 1/2/3) are essential steps in the production of functionally active viral proteins [176] . These tasks are performed by kinases, such as Cyclin-.....
Document: After being translated, proteins are transported to the Golgi network, where they are modified. Modifications, such as glycosylation of HA and NA, palmitoylation/Sacylation of HA and M2, phosphorylation of NS1, and SUMOylation of M1, NS1, NP, PB1 and NEP by SU-MO-1/2/3 (Small Ubiquitin-like Modifier type 1/2/3) are essential steps in the production of functionally active viral proteins [176] . These tasks are performed by kinases, such as Cyclin-Dependent Kinases (CDKs) and extracellular signal-regulated kinases (ERKs) [177] . Proteins are retrogradely transported by COPI and Rab8 from the trans-Golgi apparatus to the cis-Golgi and ER [178] . The quality of protein folding and the correctness of posttranslational processing are checked by proteins such as malectin, calnexin, calreticulin and ERp57 [179] [180] [181] [182] [183] .
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