Author: Ouahrouch, Abdelaaziz; Taourirte, Moha; Schols, Dominique; Snoeck, Robert; Andrei, Graciela; Engels, Joachim W.; Lazrek, Hassan B.
Title: Design, Synthesis, and Antiviral Activity of Novel Ribonucleosides of 1,2,3-Triazolylbenzyl-aminophosphonates Document date: 2015_11_17
ID: 25dwlzpy_11
Snippet: The antiviral activities of the synthesized compounds (4a-j, 5a-j) were tested against different viruses: HIV-1 and HIV-2 in MT4 cell cultures; herpes simplex virus-1 (HSV-1) (Kos strain), herpes simplex virus-2 (HSV-2) (G strain), HSV-1 thymidine kinase deficient, acyclovir-resistant (TK À Kos, ACV r ), vaccinia virus, vesicular stomatitis virus (VSV), adenovirus-2, varicella- a) All products were characterized by 1 H NMR, 13 C NMR, and mass sp.....
Document: The antiviral activities of the synthesized compounds (4a-j, 5a-j) were tested against different viruses: HIV-1 and HIV-2 in MT4 cell cultures; herpes simplex virus-1 (HSV-1) (Kos strain), herpes simplex virus-2 (HSV-2) (G strain), HSV-1 thymidine kinase deficient, acyclovir-resistant (TK À Kos, ACV r ), vaccinia virus, vesicular stomatitis virus (VSV), adenovirus-2, varicella- a) All products were characterized by 1 H NMR, 13 C NMR, and mass spectrometry. b) Yields of isolated products for the CuAAC reaction. c) Yields of isolated products for the protection reaction.
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