Author: Andrés Pizzorno; Blandine Padey; Thomas Julien; Sophie Trouillet-Assant; Aurélien Traversier; Elisabeth Errazuriz-Cerda; Julien Fouret; Julia Dubois; Alexandre Gaymard; François-Xavier Lescure; Victoria Dulière; Pauline Brun; Samuel Constant; Julien Poissy; Bruno Lina; Yazdan Yazdanpanah; Olivier Terrier; Manuel Rosa-Calatrava
Title: Characterization and treatment of SARS-CoV-2 in nasal and bronchial human airway epithelia Document date: 2020_4_2
ID: bw9lbzvt_2
Snippet: As with most emerging viral diseases, no specific antiviral treatment nor vaccine against any of these three coronaviruses are currently available, with standard patient management relying 60 mainly on symptom treatment and respiratory support when needed. In that regard, and considering that key features of the biology of SARS-CoV-2 and its induced COVID-19 still require further characterization, the scarce readiness of biologically relevant pre.....
Document: As with most emerging viral diseases, no specific antiviral treatment nor vaccine against any of these three coronaviruses are currently available, with standard patient management relying 60 mainly on symptom treatment and respiratory support when needed. In that regard, and considering that key features of the biology of SARS-CoV-2 and its induced COVID-19 still require further characterization, the scarce readiness of biologically relevant pre-clinical experimental models of SARS-CoV-2 infection as a complement of the African green monkey VeroE6 cell line represents a major barrier for scientific and medical progress in this area. We and others have previously functional and innate immune features of the human respiratory epithelium that play a central role 70 in the early stages of infection and constitute robust surrogates to study airway disease mechanisms and for drug discovery (10).
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