Selected article for: "adverse prognostic factor and initial presentation"

Author: Robinson, Lary A; Smith, Prudence; SenGupta, Dhruba J; Prentice, Jennifer L; Sandin, Ramon L
Title: Molecular analysis of sarcoidosis lymph nodes for microorganisms: a case–control study with clinical correlates
  • Document date: 2013_12_21
  • ID: 3unap1o9_87
    Snippet: Perhaps the most intriguing findings came from correlation of the PCR findings with the clinical information. All patients with lymph nodes containing bacteria DNA on presentation were also highly symptomatic and 75% of them had the poorer-prognosis radiographic stage II findings. Moreover, after a median 4 years follow-up, all bacterial DNA-positive patients were still highly symptomatic. This striking correlation strongly suggests that demonstr.....
    Document: Perhaps the most intriguing findings came from correlation of the PCR findings with the clinical information. All patients with lymph nodes containing bacteria DNA on presentation were also highly symptomatic and 75% of them had the poorer-prognosis radiographic stage II findings. Moreover, after a median 4 years follow-up, all bacterial DNA-positive patients were still highly symptomatic. This striking correlation strongly suggests that demonstration of bacterial DNA by PCR in lymph nodes on initial presentation is an adverse prognostic factor and makes it unlikely that these patients will have a spontaneous remission.

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