Author: Pipirou, Zoi; Powlesland, Alex S; Steffen, Imke; Pöhlmann, Stefan; Taylor, Maureen E; Drickamer, Kurt
Title: Mouse LSECtin as a model for a human Ebola virus receptor Document date: 2011_1_21
ID: 41i20yuy_3
Snippet: Use of the knockout mice (Tang et al. 2009 ) and other mouse-specific tools to model interactions of the human receptor is based on the assumption that the human and mouse proteins function similarly. From the work with DC-SIGN and its homologues, which provides precedent for rapid evolution of function in this region of the genome, as well as the presence of some potentially important differences in the sequences of human and mouse LSECtin, ther.....
Document: Use of the knockout mice (Tang et al. 2009 ) and other mouse-specific tools to model interactions of the human receptor is based on the assumption that the human and mouse proteins function similarly. From the work with DC-SIGN and its homologues, which provides precedent for rapid evolution of function in this region of the genome, as well as the presence of some potentially important differences in the sequences of human and mouse LSECtin, there is need for empirical evidence comparing the biochemical properties of the two receptors in order to provide a foundation for extrapolating results from mice to humans.
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