MRI findings of neuronal ceroid lipofuscinosis in a cat

White, Crystal; Mortier, Jeremy; Verin, Ranieri; Maddox, Thomas; Goncalves, Rita; Sanchez-Masian, Daniel

Following the presumptive diagnosis of neurodegenerative lysosomal storage disease and worsening of clinical signs the cat was euthanased on humane grounds and underwent a full post-mortem examination. Grossly, the meninges were diffusely moderately thickened and the brain showed moderate diffuse and bilateral cortical atrophy with narrowing of gyri and widening of sulci The cat's left is on the right. Symmetric ventriculomegaly is apparent (*). There is poor white matter/grey matter distinction owing to diffuse hyperintensity of the white matter on T2W sequence. Marked cortical atrophy and widening of the cerebral sulci are visible (black arrow). Generalised, even calvarial hyperostosis is noted (white arrow) ( Figure 3a ). Subjectively, a mild dilation of the ventricular system was observed. Sections of meninges and relevant areas of the brain and cerebellum, including motor, somatosensory, limbic, vestibular and visual system, were sampled for histopathology and transmission electron microscopy (TEM). Samples of the spinal cord at the level of the cervical and lumbosacral intumescences (C5-T1 and L3-L6, respectively) were also obtained for histopathology.