Selected article for: "cell response and ifn type"
Author: Daniels, Keith A.; Devora, Gene; Lai, Wayne C.; O'Donnell, Carey L.; Bennett, Michael; Welsh, Raymond M.
Title: Murine Cytomegalovirus Is Regulated by a Discrete Subset of Natural Killer Cells Reactive with Monoclonal Antibody to Ly49h
  • Document date: 2001_7_2
    • ID: 6n3dmle6_34
    Snippet: Viral Specificity of the NK Cell Response. Mice treated with mAb 1F8 were also infected with LCMV or VV as specificity controls and to ensure that the 1F8 mAb (which was column purified) was not contaminated with an antiviral agent or an agent that induces an antiviral effect, such as type I IFN. In contrast to the results with MCMV, this treatment did not elevate the titers of either of those vi-ruses. This is not very surprising, as LCMV is ver.....
    Document: Viral Specificity of the NK Cell Response. Mice treated with mAb 1F8 were also infected with LCMV or VV as specificity controls and to ensure that the 1F8 mAb (which was column purified) was not contaminated with an antiviral agent or an agent that induces an antiviral effect, such as type I IFN. In contrast to the results with MCMV, this treatment did not elevate the titers of either of those vi-ruses. This is not very surprising, as LCMV is very resistant to NK cells (36) , and the sensitivity of VV to NK cells can be obscured by the presence of ␥␦ T cells or by rapid stimulation of memory ␣␤ T cells (24, 31) . Infectivity studies with these viruses were therefore not continued.

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