Selected article for: "ER localization and retrieval retention"
Title: Endoplasmic reticulum localization of Sec12p is achieved by two mechanisms: Rer1p-dependent retrieval that requires the transmembrane domain and Rer1p-independent retention that involves the cytoplasmic domain
  • Document date: 1996_7_2
    • ID: 45x96b5d_5
    Snippet: On the other hand, little is known about structural requirements for Secl2p to be localized to the ER. According to our hypothesis, Secl2p should possess two localization signals corresponding to the two mechanisms, retention and retrieval. To identify these signals, we performed a systematic analysis on Secl2p localization using chimeric proteins between Secl2p and Dap2p. Dap2p is a type II transmembrane protein in the vacuole and has been claim.....
    Document: On the other hand, little is known about structural requirements for Secl2p to be localized to the ER. According to our hypothesis, Secl2p should possess two localization signals corresponding to the two mechanisms, retention and retrieval. To identify these signals, we performed a systematic analysis on Secl2p localization using chimeric proteins between Secl2p and Dap2p. Dap2p is a type II transmembrane protein in the vacuole and has been claimed to have no particular localization information in itself (Roberts et al., 1992) . In this paper, we report the results of our analysis on the chimeric proteins and present evidence that two different regions of Secl2p are important for the ER localization.

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