Selected article for: "BM1 strain and mucosal vaccine"
Author: Kim, Sae-Hae; Cho, Byeol-Hee; Lee, Kyung-Yeol; Jang, Yong-Suk
Title: N-terminal Domain of the Spike Protein of Porcine Epidemic Diarrhea Virus as a New Candidate Molecule for a Mucosal Vaccine
  • Document date: 2018_6_15
    • ID: 4vx7ez7s_24
    Snippet: The current use of PEDV-attenuated vaccines is associated with several problems, including inefficient protective immune induction against the currently prevalent PEDV strains and poor immune induction in the mucosal compartment, which includes the gastrointestinal tract, the main site of PEDV infection (22) . Consequently, application of an oral mucosal vaccine using a recombinant Ag against the currently prevalent PEDV strains should be conside.....
    Document: The current use of PEDV-attenuated vaccines is associated with several problems, including inefficient protective immune induction against the currently prevalent PEDV strains and poor immune induction in the mucosal compartment, which includes the gastrointestinal tract, the main site of PEDV infection (22) . Consequently, application of an oral mucosal vaccine using a recombinant Ag against the currently prevalent PEDV strains should be considered in the development of effective PEDV vaccines. One candidate Ag to be used as a recombinant PEDV vaccine is the S1 protein, although it is clear that the production of recombinant PEDV S1 protein in a prokaryotic expression system is not plausible. Herein, we addressed these issues and discussed the potential use of NTD 231-501 of the S1 protein from the PEDV BM1 strain, a currently prevalent strain in South Korea, as a mucosal vaccine candidate Ag.

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