Author: Sadikot, Ruxana T.; Kolanjiyil, Arun V.; Kleinstreuer, Clement; Rubinstein, Israel
Title: Nanomedicine for Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome Document date: 2017_6_27
ID: 27gutwjd_19
Snippet: Firstly we detected the fold change in TREM1 gene induced by LP17 and LP17 nanomedicine in lungs of mice. LP17 inhibited the expression of TREM1; however, there was a significantly lower expression of the TREM1 gene in response to LP17 nanomedicine. Furthermore, the inflammatory parameters including total and neutrophil cell count, cytokines and chemokines, and lung myeloperoxidase were significantly lower in mice that received LP17 nanomedicine .....
Document: Firstly we detected the fold change in TREM1 gene induced by LP17 and LP17 nanomedicine in lungs of mice. LP17 inhibited the expression of TREM1; however, there was a significantly lower expression of the TREM1 gene in response to LP17 nanomedicine. Furthermore, the inflammatory parameters including total and neutrophil cell count, cytokines and chemokines, and lung myeloperoxidase were significantly lower in mice that received LP17 nanomedicine compared to other control groups. These data suggest that nanomicellar preparation of TREM1 inhibitory peptide is more efficacious than naked peptide, and can effectively mitigate lung inflammation in LPS-induced lung injury.
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