Author: Fung, To Sing; Liu, Ding Xiang
Title: Post-translational modifications of coronavirus proteins: roles and function Document date: 2018_5_21
ID: 38c28tw1_20
Snippet: O-linked glycosylation is not essential for the assembly of MHV virions, as mutations that abolished the normal O-linked glycosylation site did not inhibit the budding of infectious virions [103] or growth kinetics in cell culture [104] . However, it was found that recombinant MHV containing N-linked glycosylated M protein induced a higher level of type I interferon compared with the wild-type MHV with O-linked glycosylated M protein, whereas MHV.....
Document: O-linked glycosylation is not essential for the assembly of MHV virions, as mutations that abolished the normal O-linked glycosylation site did not inhibit the budding of infectious virions [103] or growth kinetics in cell culture [104] . However, it was found that recombinant MHV containing N-linked glycosylated M protein induced a higher level of type I interferon compared with the wild-type MHV with O-linked glycosylated M protein, whereas MHV with nonglycosylated M protein was a poor interferon inducer in cell culture [104] . The in vitro interferongenic capacity also correlated with the abilities of these viruses to replicate in the liver of infected mice, suggesting that glycosylation status of M protein might affect the induction of innate immune response by MHV infection [104] .
Search related documents:
Co phrase search for related documents- cell culture and growth kinetic: 1
- cell culture and high level: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cell culture and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cell culture and infected mouse: 1, 2, 3, 4, 5, 6, 7, 8
- cell culture and infectious virion: 1, 2, 3, 4, 5, 6
- cell culture and innate immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22
- cell culture and innate immune response induction: 1
- cell culture and interferon inducer: 1
- cell culture and interferon type: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
- glycosylation site and high level: 1, 2
- glycosylation site and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- glycosylation site and innate immune response: 1, 2
- glycosylation status and high level: 1
- glycosylation status and immune response: 1
- glycosylation status and interferon inducer: 1
- high level and infectious virion: 1
- high level and innate immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- high level and interferon type: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- high level and interferon type high level: 1, 2
Co phrase search for related documents, hyperlinks ordered by date