Selected article for: "immune response and innate response"
Author: Fausther-Bovendo, Hugues; Kobinger, Gary P
Title: Pre-existing immunity against Ad vectors: Humoral, cellular, and innate response, what's important?
  • Document date: 2014_11_1
    • ID: 3894l9qi_12
    Snippet: In addition to Ad specific T and B cells, innate immune responses to Ad vectors can also dampen Ad efficacy, especially in the context of pre-existing immunity. The innate immune response does not possess immunological memory, with the exception of NK cells when previously activated by haptens 36 or cytokines. 37 However, despite this lack of "conventional" memory, Ad induced innate immune responses can regulate Ad immunogenicity......
    Document: In addition to Ad specific T and B cells, innate immune responses to Ad vectors can also dampen Ad efficacy, especially in the context of pre-existing immunity. The innate immune response does not possess immunological memory, with the exception of NK cells when previously activated by haptens 36 or cytokines. 37 However, despite this lack of "conventional" memory, Ad induced innate immune responses can regulate Ad immunogenicity.

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