Author: Mok, Hoyin; Cheng, Xing; Xu, Qi; Zengel, James R; Parhy, Bandita; Zhao, Jackie; Wang, C. Kathy; Jin, Hong
Title: Evaluation of Measles Vaccine Virus as a Vector to Deliver Respiratory Syncytial Virus Fusion Protein or Epstein-Barr Virus Glycoprotein gp350 Document date: 2012_2_16
ID: 3qdjmb2j_41
Snippet: Other negative stranded RNA viruses including Newcastle disease virus (NDV), vesicular stomatitis virus, Sendai virus and parainfluenza viruses [35, [63] [64] [65] had been evaluated as vectors to deliver foreign antigens and were shown to elicit both humoral and cellular responses in nonhuman primates and to confer protection to virus challenge in some cases [63, [66] [67] [68] [69] . The vectored vaccines were normally delivered to non-human pr.....
Document: Other negative stranded RNA viruses including Newcastle disease virus (NDV), vesicular stomatitis virus, Sendai virus and parainfluenza viruses [35, [63] [64] [65] had been evaluated as vectors to deliver foreign antigens and were shown to elicit both humoral and cellular responses in nonhuman primates and to confer protection to virus challenge in some cases [63, [66] [67] [68] [69] . The vectored vaccines were normally delivered to non-human primates by either intranasal or intratracheal inoculation route. We found intranasal and intramuscular vaccination of EZ induced similar antibody response in cotton rats. It is possible that intranasal immunization might be more immunogenic than intramuscular vaccination in monkeys.
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