Author: Sabath, Niv; Wagner, Andreas; Karlin, David
Title: Evolution of Viral Proteins Originated De Novo by Overprinting Document date: 2012_7_19
ID: 629fwmgk_38
Snippet: Our results have two practical implications. First, they suggest that recently evolved genes might have strain-specific functions, or possibly no function, as suggested previously (Trifonov and Rabadan 2009 ) for PB1-F2 (taxon 1), the youngest de novo genes in our data set. Experimental studies should thus take this possibility into account. Our current method to estimate dN/dS does not tell us whether the elevated dN/dS values observed in some y.....
Document: Our results have two practical implications. First, they suggest that recently evolved genes might have strain-specific functions, or possibly no function, as suggested previously (Trifonov and Rabadan 2009 ) for PB1-F2 (taxon 1), the youngest de novo genes in our data set. Experimental studies should thus take this possibility into account. Our current method to estimate dN/dS does not tell us whether the elevated dN/dS values observed in some young de novo genes indicate neutral evolution or positive selection. However, it is possible that they come not only from neutral mutations but also from beneficial mutations subject to positive selection, which would reflect evolutionary adaptations.
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