Selected article for: "dose fractionation and vaccine efficacy"
Author: Wu, Joseph T.; Peak, Corey M.; Leung, Gabriel M.; Lipsitch, Marc
Title: Fractional Dosing of Yellow Fever Vaccine to Extend Supply: A Modeling Study
  • Document date: 2016_11_10
    • ID: 02pjdufw_78
    Snippet: We estimate that the reproductive number of the YF epidemic in Angola during 2016 is 5·2 to 7·1. Our study is the first to provide an estimate of the transmissibility of YF in urban settings. We characterize the threshold of vaccine efficacy above which dosesparing can drastically reduce the number of YF cases. We show how the benefits of dose fractionation are influenced by the transmission intensity of the setting, the target coverage, and th.....
    Document: We estimate that the reproductive number of the YF epidemic in Angola during 2016 is 5·2 to 7·1. Our study is the first to provide an estimate of the transmissibility of YF in urban settings. We characterize the threshold of vaccine efficacy above which dosesparing can drastically reduce the number of YF cases. We show how the benefits of dose fractionation are influenced by the transmission intensity of the setting, the target coverage, and the fractional-dose vaccine efficacy and mode of action. We show that the WHO dose-sparing strategy for the Kinshasa vaccination campaign in July-August 2006 is a robust and effective strategy for reducing infection attack rate that would be robust with a large margin for error in case five-fold fractional-dose vaccine efficacy turns out to be lower than expected.

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