Selected article for: "airway inflammation and allergic inflammatory airway"
Author: Hur, Gyu Young; Broide, David H.
Title: Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma
  • Document date: 2019_6_4
    • ID: 6j3k3viu_19
    Snippet: TSLP is an epithelial cell-derived cytokine that triggers Th2-inflammatory responses and is highly expressed in airway epithelial cells during allergic inflammation. 35 In asthmatics, both TSLP and Th2-cytokine mRNA are increased, and TSLP mRNA expression is inversely correlated with FEV1%. 36 Limited studies have investigated the contribution of SNPs in TSLP to asthma outcomes including lung function in asthma. For example, the TSLP genetic vari.....
    Document: TSLP is an epithelial cell-derived cytokine that triggers Th2-inflammatory responses and is highly expressed in airway epithelial cells during allergic inflammation. 35 In asthmatics, both TSLP and Th2-cytokine mRNA are increased, and TSLP mRNA expression is inversely correlated with FEV1%. 36 Limited studies have investigated the contribution of SNPs in TSLP to asthma outcomes including lung function in asthma. For example, the TSLP genetic variant rs2289278 CC allele was significantly correlated with decreased FEV1/FVC in adult asthmatics in Japan (641 adult asthmatics and 376 controls). 37 A study in non-asthmatics did not find an association with TSLP SNPs and decline in lung function. At present no published study has investigated whether TSLP genetic variants are associated with features of airway remodeling.

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