Author: Hur, Gyu Young; Broide, David H.
Title: Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma Document date: 2019_6_4
ID: 6j3k3viu_32
Snippet: To date, there has been only one published genetic polymorphism study of periostin and decline in lung function in asthma. Periostin is encoded by the POSTN gene, which is located on chromosome 13q13.3. The POSTN SNP rs9603226 minor A allele, located at the 66 bp upstream of exon 21 in the C-terminal region, has been associated with a rapid decline in FEV1 of 30 mL or greater per year in a study of 224 asthmatics in Japan (P = 0.01). 53 No studie.....
Document: To date, there has been only one published genetic polymorphism study of periostin and decline in lung function in asthma. Periostin is encoded by the POSTN gene, which is located on chromosome 13q13.3. The POSTN SNP rs9603226 minor A allele, located at the 66 bp upstream of exon 21 in the C-terminal region, has been associated with a rapid decline in FEV1 of 30 mL or greater per year in a study of 224 asthmatics in Japan (P = 0.01). 53 No studies have reported whether POSTN SNPs are linked to airway remodeling.
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