Selected article for: "fit model and sequence evolution"
Author: Joana Damas; Graham M. Hughes; Kathleen C. Keough; Corrie A. Painter; Nicole S. Persky; Marco Corbo; Michael Hiller; Klaus-Peter Koepfli; Andreas R. Pfenning; Huabin Zhao; Diane P. Genereux; Ross Swofford; Katherine S. Pollard; Oliver A. Ryder; Martin T. Nweeia; Kerstin Lindblad-Toh; Emma C. Teeling; Elinor K. Karlsson; Harris A. Lewin
Title: Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates
  • Document date: 2020_4_18
    • ID: 6ne76rh1_26
    Snippet: . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.16.045302 doi: bioRxiv preprint Evolution of ACE2 across mammals . We next investigated the evolution of ACE2 variation in vertebrates, including how patterns of positive selection compare between bats, a mammalian lineage known to harbor a diversity of co.....
    Document: . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.16.045302 doi: bioRxiv preprint Evolution of ACE2 across mammals . We next investigated the evolution of ACE2 variation in vertebrates, including how patterns of positive selection compare between bats, a mammalian lineage known to harbor a diversity of coronaviruses (35) , and other mammalian clades. We first inferred the phylogeny of ACE2 using our 410-vertebrate alignment and IQTREE, using the best-fit model of sequence evolution (JTT+F+R7) and rooting the topology on fishes (Dataset S3; Fig. S3 ). We then assayed sequence conservation with PhyloP (36) . The majority of ACE2 codons are significantly conserved across vertebrates and across mammals, likely reflecting its critical function in the renin-angiotensin system (37) (Dataset S4.1), with ten residues in the ACE2 binding domain exceptionally conserved in Chiroptera and/or Rodentia (Dataset S4.2).

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