Author: Joana Damas; Graham M. Hughes; Kathleen C. Keough; Corrie A. Painter; Nicole S. Persky; Marco Corbo; Michael Hiller; Klaus-Peter Koepfli; Andreas R. Pfenning; Huabin Zhao; Diane P. Genereux; Ross Swofford; Katherine S. Pollard; Oliver A. Ryder; Martin T. Nweeia; Kerstin Lindblad-Toh; Emma C. Teeling; Elinor K. Karlsson; Harris A. Lewin
Title: Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates Document date: 2020_4_18
ID: 6ne76rh1_37
Snippet: Relationship of the ACE2 binding score to known infectivity of SARS-CoV-2 . Data on susceptibility of wild animals to SARS-CoV-2 is still very limited. It has been reported that a captive Malayan tiger was infected by SARS-CoV-2 (9) and that domestic cats, ferrets (47) , rhesus macaques (48) and Syrian golden hamsters (49) are susceptible to experimental infection by SARS-CoV-2. These results agree with our predictions of ACE2 binding ability to .....
Document: Relationship of the ACE2 binding score to known infectivity of SARS-CoV-2 . Data on susceptibility of wild animals to SARS-CoV-2 is still very limited. It has been reported that a captive Malayan tiger was infected by SARS-CoV-2 (9) and that domestic cats, ferrets (47) , rhesus macaques (48) and Syrian golden hamsters (49) are susceptible to experimental infection by SARS-CoV-2. These results agree with our predictions of ACE2 binding ability to SARS-CoV-2 S (Fig. 1 , Dataset S1); 4/5 five species with demonstrated susceptibility to SARS-CoV-2 score very high (Rhesus macaque) or medium (domestic cat, tiger and Golden hamster). The only inconsistency was observed for ferrets, which had a low ACE2 binding score. This inconsistency could be related to the high infectivity dose used for experimental infection that likely does not correspond to virus exposure in nature. Dogs have low susceptibility to SARS-CoV-2 under experimental conditions (47) , and score low for binding of their ACE2 to SARS-CoV-2 S. However, kidney cell lines derived from dog showed ACE2-dependent SARS-CoV-2 S entry, suggesting that in vitro experiments may be overestimating true infectivity potential (39, 50) . Pigs ( low ), ducks ( very low ) and chickens ( very low ) were similarly exposed to SARS-CoV-2 and showed no susceptibility (47) , providing further support of our methodology. A recent publication reporting that SARS-CoV-2 could use pig, masked palm civet and Chinese rufous horseshoe bat ACE2 expressed in HeLa cells were inconsistent with our predictions, while data for mouse was in agreement (1) . Indeed, while mouse ACE2 (54, 55) and bottlenose dolphins (56) and are associated with respiratory diseases, the cellular receptor used by these viruses is not known.
Search related documents:
Co phrase search for related documents- bind ability and cellular receptor: 1, 2, 3, 4
- bind ability and HeLa cell: 1
- binding score and cell line: 1
- binding score and experimental infection: 1
- binding score and golden hamster: 1
- binding score and HeLa cell: 1
- cell line and demonstrate susceptibility: 1
- cell line and experimental condition: 1, 2, 3
- cell line and experimental infection: 1, 2, 3, 4, 5, 6, 7, 8, 9
- cell line and golden hamster: 1, 2
- cell line and HeLa cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cell line and HeLa cell express: 1
- cell line and horseshoe bat: 1
- cellular receptor and experimental infection: 1, 2, 3
- cellular receptor and HeLa cell: 1
- cellular receptor and horseshoe bat: 1, 2, 3
- chinese rufous horseshoe bat and domestic cat: 1
- chinese rufous horseshoe bat and horseshoe bat: 1, 2, 3, 4, 5
- domestic cat and horseshoe bat: 1, 2
Co phrase search for related documents, hyperlinks ordered by date