Selected article for: "age range and gene mutation"
Author: Yen, Wei-Chen; Wu, Yi-Hsuan; Wu, Chih-Ching; Lin, Hsin-Ru; Stern, Arnold; Chen, Shih-Hsiang; Shu, Jwu-Ching; Tsun-Yee Chiu, Daniel
Title: Impaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX/p38 MAPK/AP-1 redox signaling
  • Document date: 2019_11_2
    • ID: 6fw4thkq_37
    Snippet: Ten patients with G6PD deficiency and 10 healthy controls were recruited for this study (Table 1) . Of the patients with G6PD deficiency and the normal controls, all subjects were within an age range of 20-70. The point mutation sites of the G6PD gene from patients with G6PD deficiency are 1376 and 1388 ( Table 1 ). The G6PD activity of whole blood from patients with G6PD deficiency was much lower than that of the normal controls (Fig. 1A) . IL-1.....
    Document: Ten patients with G6PD deficiency and 10 healthy controls were recruited for this study (Table 1) . Of the patients with G6PD deficiency and the normal controls, all subjects were within an age range of 20-70. The point mutation sites of the G6PD gene from patients with G6PD deficiency are 1376 and 1388 ( Table 1 ). The G6PD activity of whole blood from patients with G6PD deficiency was much lower than that of the normal controls (Fig. 1A) . IL-1β secretion was significantly decreased in G6PD-deficient human PBMCs (Fig. 1B) compared to that in normal control PBMCs, indicating that G6PD deficiency is associated with lower IL-1β production. The activity of G6PD was positively correlated with the secretion of IL-1β (Fig. 1C) .

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