Selected article for: "antibiotic treatment and empirical treatment"
Author: Meyer Sauteur, Patrick M; Krautter, Selina; Ambroggio, Lilliam; Seiler, Michelle; Paioni, Paolo; Relly, Christa; Capaul, Riccarda; Kellenberger, Christian; Haas, Thorsten; Gysin, Claudine; Bachmann, Lucas M; van Rossum, Annemarie M C; Berger, Christoph
Title: Improved Diagnostics Help to Identify Clinical Features and Biomarkers That Predict Mycoplasma pneumoniae Community-acquired Pneumonia in Children
  • Document date: 2019_10_26
    • ID: 1xkc01l5_30
    Snippet: Mp infection is mild and self-limiting in most cases, and manifests predominantly in previously healthy children [5] . In our study, one-third of Mp-positive CAP patients were not treated with an antibiotic in vitro active against Mp, but all of these children fully recovered. The BTS guidelines advise that macrolide antibiotics may be added at any age in case of very severe disease or if there is no response to first-line empirical treatment [2].....
    Document: Mp infection is mild and self-limiting in most cases, and manifests predominantly in previously healthy children [5] . In our study, one-third of Mp-positive CAP patients were not treated with an antibiotic in vitro active against Mp, but all of these children fully recovered. The BTS guidelines advise that macrolide antibiotics may be added at any age in case of very severe disease or if there is no response to first-line empirical treatment [2] . Prior antibiotic treatment was associated with Mp CAP and included treatment with β-lactam antibiotics in most cases. This supports that in patients that do not respond to β-lactam antibiotics, Mp CAP should be considered [2, 7] . We did not find statistical differences in fever duration following CAP diagnosis, hospital length of stay, or recovery at follow-up between Mp-positive patients who did and did not receive antibiotics against Mp (data not shown). These findings support the need for future interventional studies assessing the effect of antibiotics for Mp CAP [1, 9, 37, 38] .

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