Author: Chanaka N Kahathuduwa; Chathurika S Dhanasekara; Shao-Hua Chin
Title: Case fatality rate in COVID-19: a systematic review and meta-analysis Document date: 2020_4_6
ID: dcf6bl8f_29
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.01.20050476 doi: medRxiv preprint be 100% certain. Second, high degree of heterogeneity was a concern. However, this should be 284 expected in any meta-analysis due to the variability in methodology and study samples and we 285 used heterogeneity to explore covariates in meta-regression analyses. 18, 20 Third, funnel plots of 286 all thre.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.01.20050476 doi: medRxiv preprint be 100% certain. Second, high degree of heterogeneity was a concern. However, this should be 284 expected in any meta-analysis due to the variability in methodology and study samples and we 285 used heterogeneity to explore covariates in meta-regression analyses. 18, 20 Third, funnel plots of 286 all three meta-analyses indicating substantial publication bias, limiting the generalizability of 287 uncorrected random-effects meta-analyses. Finally, the protocol was not pre-registered. Use of a 288 systematic search strategy; use of random-effects meta-analyses and meta-regression analyses 289 assuming high heterogeneity of effect-sizes; exploring the etiology of heterogeneity in meta-290 regression analyses, which also identified risk factors of morbidity and mortality; exploring the 291 validity of our findings in sensitivity analyses; and statistically correcting for publication / 292 underreporting bias are notable strengths of our systematic review and meta-analysis.
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