Selected article for: "apoptosis process and Bax pro apoptotic gene"
Author: Yan, Xiujuan; Li, Yingxiu; Choi, Yun Ho; Wang, Chongyang; Piao, Yihua; Ye, Jing; Jiang, Jingzhi; Li, Liangchang; Xu, Huixian; Cui, Qingsong; Yan, Guanghai; Jin, Minggen
Title: Protective Effect and Mechanism of Alprostadil in Acute Respiratory Distress Syndrome Induced by Oleic Acid in Rats
  • Document date: 2018_10_8
    • ID: 7ea7ur3b_5
    Snippet: Dysregulation of apoptosis pathways can result in epithelial injury, which is the characteristic of ALI [23, 24] . The Bcl-2 family, including an anti-apoptotic gene (Bcl-2) and a pro-apoptotic gene (Bax), is also closely associated with apoptosis [25] . The sensitivity to apoptotic signals mainly depends on the process of competitive dimerization of Bcl-2/Bax in cells. When Bcl-2 is expressed at a high level, Bcl-2/Bcl-2 homodimer and Bcl-2/Bax .....
    Document: Dysregulation of apoptosis pathways can result in epithelial injury, which is the characteristic of ALI [23, 24] . The Bcl-2 family, including an anti-apoptotic gene (Bcl-2) and a pro-apoptotic gene (Bax), is also closely associated with apoptosis [25] . The sensitivity to apoptotic signals mainly depends on the process of competitive dimerization of Bcl-2/Bax in cells. When Bcl-2 is expressed at a high level, Bcl-2/Bcl-2 homodimer and Bcl-2/Bax heterodimer are created and the DNA cleavage activity of endonuclease is inhibited to suppress apoptosis. When Bax is overexpressed, Bax/Bax homodimer is formed to accelerate apoptosis. Finally, it has been demonstrated that the ratio of Bcl-2 to Bax is a crucial index in the process of apoptosis, indicating the severity of apoptosis [26] . Strategies to block apoptosis pathways could be effective for limiting ALI.

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