Antiviral and Anti-Inflammatory Activities of Pochonin D, a Heat Shock Protein 90 Inhibitor, against Rhinovirus Infection

Song, Jae-Hyoung; Shim, Aeri; Kim, Yeon-Jeong; Ahn, Jae-Hee; Kwon, Bo-Eun; Pham, Thuy Trang; Lee, Jongkook; Chang, Sun-Young; Ko, Hyun-Jeong

Several inhibitors of Hsp90 are known and their potential as therapeutic drugs have been tested at both preclinical and clinical stages (Neckers and Workman, 2012) . Radicicol is a natural product and is reported as one of the most potent Hsp90 inhibitors (Moulin et al., 2005) . It can selectively block the function of ATPase and the chaperone function of Hsp90 (Roe et al., 1999; Zhou et al., 2010) . Despite its potent activity, radicicol has labile moieties that are rapidly inactivated in vivo, leading to poor efficacy in practice (Zhou et al., 2010) . Pochonin D was originally isolated from Pochonia chlamydosporia and is a radicicol analog with potential Hsp90 inhibitory ability (Moulin et al., 2005; Wang et al., 2016; Choe et al., 2017) . It has been shown to inhibit the replication of Herpes Simplex Virus 1 (HSV1) and the parasitic protozoan Eimeria tenella (Hellwig et al., 2003) .