Author: Ganesan, Shyamala; Comstock, Adam T; Sajjan, Uma S
Title: Barrier function of airway tract epithelium Document date: 2013_10_1
ID: 332eygtr_8
Snippet: Mucociliary dysfunction, in addition to causing obstruction of airways, may also promote recurrent and persistent respiratory infections as evidenced in patients with cystic fibrosis, ciliary dyskinesia, and COPD. [73] [74] [75] [76] Mucin glycoproteins have been shown to interact with several respiratory pathogens including Pseudomonas aeruginosa, Staphylococcus aureus, Heamophilus influenzae, Streptococcus pneumonia, Burkholderia cenocepacia, i.....
Document: Mucociliary dysfunction, in addition to causing obstruction of airways, may also promote recurrent and persistent respiratory infections as evidenced in patients with cystic fibrosis, ciliary dyskinesia, and COPD. [73] [74] [75] [76] Mucin glycoproteins have been shown to interact with several respiratory pathogens including Pseudomonas aeruginosa, Staphylococcus aureus, Heamophilus influenzae, Streptococcus pneumonia, Burkholderia cenocepacia, influenza virus, adenovirus, and coronavirus. [77] [78] [79] [80] [81] [82] [83] The bound pathogens which are cleared under normal conditions may persist in the airway lumen when the mucociliary clearance is impaired, and initiate an inflammatory response which can damage the airway epithelium. However, the impact of the interaction of mucin glycoproteins with pathogens in vivo is yet to be established.
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