2016 ACVIM Forum Research Abstract Program

Splenic fine-needle aspirate is a minimally invasive diagnostic modality providing information that changed case management in 1/5 adult dogs with splenic nodules or heterogeneous splenic parenchyma, and should be considered in this population of patients. After a 12 hour fast, 8 cats received 50 mg (~12.7 mg/kg) of itraconazole (SporanoxÃ’ capsule, SporanoxÃ’ solution, compounded capsule, and compounded suspension) in a randomized crossover with a 21-day washout. Capsules were administered with a small meal whereas solution was not. Plasma was collected at pre-determined intervals for analysis using high pressure liquid chromatography. Compartmental and non-compartmental pharmacokinetic analyses were performed using PhoenixÃ’ software (Certara) on the proprietary SporanoxÃ’ and compounded formulation data, respectively.