Selected article for: "efficacy evaluation and study purpose"
Title: 2016 ACVIM Forum Research Abstract Program
  • Document date: 2016_5_31
    • ID: 2y1y8jpx_741
    Snippet: Alexandra Bianco, George Moore, Sandra Taylor. Purdue University, West Lafayette, IN, USA Non-steroidal anti-inflammatory drugs (NSAIDs) play an integral role in equine medicine due to their combined analgesic and anti-inflammatory properties. Despite their widespread use, there are limited NSAIDs available that demonstrate variable adverse effects and safety. While several NSAIDs have been proven to be adequate analgesics, few have undergone rig.....
    Document: Alexandra Bianco, George Moore, Sandra Taylor. Purdue University, West Lafayette, IN, USA Non-steroidal anti-inflammatory drugs (NSAIDs) play an integral role in equine medicine due to their combined analgesic and anti-inflammatory properties. Despite their widespread use, there are limited NSAIDs available that demonstrate variable adverse effects and safety. While several NSAIDs have been proven to be adequate analgesics, few have undergone rigorous evaluation for anti-inflammatory efficacy. Ketorolac tromethamine (KT) is a nonselective cyclooxygenase inhibitor that has been used in human patients since 1989. The pharmacokinetic properties of KT have recently been determined in the horse, and have been previously determined in several other species. However, there have been only two previous studies examining KT's anti-inflammatory properties in animals, both of which were in vivo. There have been no published studies evaluating the in vitro anti-inflammatory effects of KT in any veterinary species. The purpose of this study was to evaluate the anti-inflammatory effects of KT compared to flunixin meglumine using an in vitro model of LPS-stimulated equine monocytes.

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