Author: Drummond, Sheona P.; Hildyard, John; Firczuk, Helena; Reamtong, Onrapak; Li, Ning; Kannambath, Shichina; Claydon, Amy J.; Beynon, Robert J.; Eyers, Claire E.; McCarthy, John E. G.
Title: Diauxic shift-dependent relocalization of decapping activators Dhh1 and Pat1 to polysomal complexes Document date: 2011_6_28
ID: 1jdcdwxo_3
Snippet: Dhh1 belongs to a family of closely related DEAD-box RNA helicases that associate with components of mRNA decapping, deadenylation and transcription complexes (1, 4) . Dhh1 stimulates mRNA decapping by the decapping enzyme complex Dcp1/Dcp2, and has been shown to localize partly to P-bodies (15) . Orthologues of Dhh1 in other eukaryotes, such as Xenopus and Drosophila, play roles in repressing translation of specific mRNAs during early developmen.....
Document: Dhh1 belongs to a family of closely related DEAD-box RNA helicases that associate with components of mRNA decapping, deadenylation and transcription complexes (1, 4) . Dhh1 stimulates mRNA decapping by the decapping enzyme complex Dcp1/Dcp2, and has been shown to localize partly to P-bodies (15) . Orthologues of Dhh1 in other eukaryotes, such as Xenopus and Drosophila, play roles in repressing translation of specific mRNAs during early development (6, 7) . Dhh1 has been suggested to play a role in partitioning mRNAs between translatable and non-translatable pools, which has been implicated in the recovery from G1/S cell-cycle arrest following DNA damage (16) . DHH1 is orthologous to the human putative proto-oncogene p54/RCK, indicating that the mechanisms of action suggested by studies of yeast are relevant to human health/disease. Moreover, a fascinating parallel exists to the involvement of Lsm1-7/Pat1/Dhh1 in the transition from an actively translating state to a nontranslating state (replication or decay competent) observed in Brome Mosaic Virus (BMV). In addition, a comparable transition is promoted in Hepatitis C Virus (HCV) by the virus-encoded NS3 helicase (e.g. 17) , suggesting that there may be common molecular principles (for example, responsible for remodelling ribonucleoprotein complex structures) operating in diverse subcellular systems.
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