Selected article for: "astrocytes IFN response and IFN response"

Title: Differential tumor necrosis factor alpha expression by astrocytes from experimental allergic encephalomyelitis-susceptible and -resistant rat strains
  • Document date: 1991_4_1
  • ID: 6acjgug3_34
    Snippet: As mentioned previously, EAE is characterized by the infiltration of mononuclear cells into the CNS, with the predominant cell types being activated T cells and macrophages. Activated T cells in the Lewis CNS could serve as an endogenous source of the rytokine IFN-y, and prime astrocytes for TNF-a expression . Infiltrating macrophages and resident astrocytes/microglia represent sources of ILI that could interact with IFN-y-primed astrocytes, resu.....
    Document: As mentioned previously, EAE is characterized by the infiltration of mononuclear cells into the CNS, with the predominant cell types being activated T cells and macrophages. Activated T cells in the Lewis CNS could serve as an endogenous source of the rytokine IFN-y, and prime astrocytes for TNF-a expression . Infiltrating macrophages and resident astrocytes/microglia represent sources of ILI that could interact with IFN-y-primed astrocytes, resulting in TNF-a production . TNF-a production by Lewis astrocytes in response to IFN-y and IIJ1 may perpetuate the influx of non-antigenspecific inflammatory cells into the CNS by increasing the permeability of endothelial cells (48) , and by enhancing expression of adhesion molecules on both brain endothelium and astrocytes (19, 49) . Additionally, astrocyte TNF-a production may kill or damage neighboring oligodendrocytes (12) and directly damage the myelin sheath (21) , contributing to demyelination .

    Search related documents:
    Co phrase search for related documents
    • adhesion molecule and cell type: 1, 2, 3, 4, 5, 6, 7, 8
    • adhesion molecule and endothelial cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32
    • adhesion molecule and inflammatory cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
    • adhesion molecule and TNF expression: 1, 2, 3, 4, 5, 6, 7, 8
    • adhesion molecule and TNF production: 1
    • adhesion molecule expression and cell type: 1, 2
    • adhesion molecule expression and endothelial cell: 1, 2, 3
    • adhesion molecule expression and inflammatory cell: 1, 2, 3
    • adhesion molecule expression and TNF expression: 1, 2, 3
    • astrocyte TNF production and cell type: 1
    • astrocyte TNF production and Lewis astrocyte: 1
    • astrocyte TNF production and TNF expression: 1