Author: Prerana Shrestha; Pinar Ayata; Pedro Herrero-Vidal; Francesco Longo; Alexandra Gastone; Joseph E. Ledoux; Nathaniel Heintz; Eric Klann
Title: Chemogenetic evidence that rapid neuronal de novo protein synthesis is required for consolidation of long-term memory Document date: 2019_7_17
ID: llzdwza1_13
Snippet: It is evident that the translation program regulated by eIF2α is necessary for LTM consolidation; 247 however, the accumulation of ATF4 raises the question of whether it is either decreased protein synthesis or 248 increased ATF4 levels causing the memory deficit. Indeed, a previous study has reported that even in the Fig. 5b ), but strongly impaired LTM (Supplemental 261 Fig. 5c and d) . Together, the LTM deficit observed using two independent .....
Document: It is evident that the translation program regulated by eIF2α is necessary for LTM consolidation; 247 however, the accumulation of ATF4 raises the question of whether it is either decreased protein synthesis or 248 increased ATF4 levels causing the memory deficit. Indeed, a previous study has reported that even in the Fig. 5b ), but strongly impaired LTM (Supplemental 261 Fig. 5c and d) . Together, the LTM deficit observed using two independent approaches for blocking translation 262 initiation in CamK2α.iPKR and CamK2α.4Ekd respectively strongly support our hypothesis that de novo 263 translation in LA Camk2α+ neurons is necessary for consolidation of long-term threat memories.
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