Author: Yu, Chenglong; Liang, Qian; Yin, Changchuan; He, Rong L.; Yau, Stephen S.-T.
Title: A Novel Construction of Genome Space with Biological Geometry Document date: 2010_4_1
ID: 3c4dttrt_2
Snippet: In Koonin' s editorial 6 about the emerging paradigm and open problems in comparative genomics, he pointed out '. . . but within these superfamilies, there is nothing like a straight one-to-one correspondence between genomes, and in distant genomes, most of the members may not be orthologous'. This sentence enlightened us to get a novel idea of comparing genomes. We can construct a genome space. In this space, each point corresponds to a genome u.....
Document: In Koonin' s editorial 6 about the emerging paradigm and open problems in comparative genomics, he pointed out '. . . but within these superfamilies, there is nothing like a straight one-to-one correspondence between genomes, and in distant genomes, most of the members may not be orthologous'. This sentence enlightened us to get a novel idea of comparing genomes. We can construct a genome space. In this space, each point corresponds to a genome uniquely. The natural distance between two points in the genome space reflects the biological distance between these two genomes. Currently, there is no method to represent genomes by a point in a space without losing biological information.
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