Author: Takamura, Shiki
Title: Persistence in Temporary Lung Niches: A Survival Strategy of Lung-Resident Memory CD8(+) T Cells Document date: 2017_7_1
ID: 2klytw6c_21
Snippet: It is well established that effector CD8 + T cells recruited to the lung subsequently encounter respiratory DC subsets that present cognate antigen. This ''second hit'' with cognate antigen at the site of infection improves the cell capacity to secrete IFN-c (88) and induces additional rounds of proliferation (87) . In addition to stimulating the CD8 + T cells, respiratory DCs trans-present IL-15 to prevent rapid apoptosis of the cells (89) . Whi.....
Document: It is well established that effector CD8 + T cells recruited to the lung subsequently encounter respiratory DC subsets that present cognate antigen. This ''second hit'' with cognate antigen at the site of infection improves the cell capacity to secrete IFN-c (88) and induces additional rounds of proliferation (87) . In addition to stimulating the CD8 + T cells, respiratory DCs trans-present IL-15 to prevent rapid apoptosis of the cells (89) . While these antigen stimulation processes regulate terminal effector differentiation, several studies have indicated that local antigen recognition also serves as a primary tissue-derived instructive factor requisite for effective T RM differentiation (9, 59, 90, 97, 123, 133) .
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