Phenol-Rich Compounds Sweet Gel: A Statistically More Effective Antibiotic than Cloxacillin Against Pseudomonas Aeruginosa

Dashtdar, Mehrab; Dashtdar, Mohammad Reza; Dashtdar, Babak; Khan, Gazala Afreen; Kardi, Karima

Pseudomonas aeruginosa (P. aeruginosa) is an aerobic gram-negative bacterium; that is ubiquitous, exist in aqueous habitats, and take advantage of humid en-vironments. It is also saprophytic and naturally resistant to antibiotics (beta-lactams, hydrophilic), and may become an opportunistic pathogen responsible for serious infections when favorable circumstances exist. Because it is environmentally present in soils, plants (including fruits and vegetables), aqueous habitats and humid environments [1], It has an ability to acquire resistance to antibiotics, and has multiplicity of virulence factors (diffusible or constituent) that baffle the host's defenses and allow the development of infections in susceptible patients, such as malnourished patients; burn victims, trauma patients, patients suffering from diabetes, cystic fibrosis, cancer, human immunodeficiency virus (HIV), and blood disorders, patients undergoing mechanical ventilation or long-term corticosteroid therapy; patients in whom carrier surveyed peripheral and central catheters are being used [2] . P. aeruginosa infections are most often acquired in a hospital, but are sometimes community acquired; Factors limiting P. aeruginosa proliferation on the skin are dryness of the skin's surface and normal flora (Gram + Cocci). The bacterium P. aeruginosa can grow or become permanent on the skin in case of the traumatic rupture of the skin barrier; chronic wounds such as leg ulcers, extensive burns, diabetes include ulcers, oozing dermatitis, and wet or macerated lesions the disappearance of Gram + Cocci normal flora caused by the use of systemic or topical antimicrobials. The first signs of infection of a chronic wound or ulcer are the production of greenish pus and the appearance of a characteristic aromatic odor. The appearance of the ulcer or wound becomes inflammatory or necrotic. These are vesicular or bullous lesions with a content of serum are hemorrhagic based on an erythematous and edematous base and can initially have the clinical appearance of multiform erythema. These lesions can change very quickly in a few days to ulceration, and they then take the appearance of a so-called ecthyma gangrenosum [3] [4] [5] [6] . One can also have abscesses or single or multiple subcutaneous nodules that can change very quickly to necrosis and ulceration.