Phenol-Rich Compounds Sweet Gel: A Statistically More Effective Antibiotic than Cloxacillin Against Pseudomonas Aeruginosa

Dashtdar, Mehrab; Dashtdar, Mohammad Reza; Dashtdar, Babak; Khan, Gazala Afreen; Kardi, Karima

Iron; also plays a key role in the healing process [23] . It preventing necrosis and accelerating the repair of radiation-induced wounds. It also promotes collagen synthesis, improves oxygen delivery to tissue, and is a component of many enzyme systems. Chronic iron deficiency or anemia is associated with an extended period of healing and oth- Prolonged supplementation may in turn affect the absorption of zinc, copper and iron. This is because copper, iron and zinc use the same routes to cross the intestinal barrier and reach the bloodstream. Therefore excessive inputs of a given mineral salt can interfere with the absorption of others. No significant benefit for wound healing is seen with nutritional supplements such as vitamins C, A, E, and zinc in a non-deficient individuals. [25] [26] [27] [28] In contrast to oral administration, topical administration of zinc appears to be superior due to its action in reducing super infections and necrotic material via enhanced local defense systems and collagenolytic activity; and to the sustained release of zinc ions, which stimulates epithelialization of wounds in normozincemic individuals. Zinc oxide in paste bandages (Unna boot) protects and soothes inflamed peri-wound skin. Zinc from these formulations is transported through the skin although the systemic effects seem insignificant. The topical administration formula that focuses on certain vitamins and nutrients applied directly on the wounds is more effective as a supplements to reduce the risk of infection and to stimulate healing. Furthermore, phenolrich compounds, provides a number of essential minerals, such as Zinc, potassium, iron, magnesium and calcium (Table 1 ). In previous studies [29-31] on phenol compounds, no contraindications and side effects have been reported to date for any of the ingredient used in our study, even though all of the benefits seem to have been reported. The topical use of phenol-rich compound sweet gel should be safer than that of the other formulations, but to be on the safe side, more clinical studies and toxicology studies need to be conducted. The antibiotic effect of phenol-rich compounds is due to the presence of hydrophilic components, such as polyphenols, polysaccharides, flavonoids and tannins in one or more parts of the plant. Thus is an innovative approach to fighting the antibiotic-resistant Pseudomonas. Our results and those of previous studies provide pharmacology and microbiology information to explain the advantages of the phenol-rich compound sweet gel and its mechanisms of action as a bioactive dressing material in treating chronic ulcer: √ Sterilization of wounds √ Rapid autolytic debridement √ Inhibition of potential pathogens of wounds and enzymes that destroy tissue, √ Stimulations of tissues growth to speed healing, √ Protection against cross-contamination, √ Reduction of scars, √ Anti-inflammatory effect: reductions of infections, deodorization of wounds, reducing edema and against maceration due reduced of exudate , √ Provision of moist healing environment without risk of surrounding skin maceration and preventions of adhesion of the dressings to the wound, thus preventing pain and tissue damage when dressing is changed. √ Low enough pH to slow or prevent the growth of many pathogenic species.