Author: Gultekin, Mehmet; Voyvoda, Huseyin; Ural, Kerem; Erdogan, Hasan; Balikci, Canberk; Gultekin, Gamze
Title: Plasma citrulline, arginine, nitric oxide, and blood ammonia levels in neonatal calves with acute diarrhea Document date: 2019_2_20
ID: 4vp7i04f_1
Snippet: primarily in the small bowel include diarrhea, dehydration, malnutrition, potentially systemic inflammatory response syndrome (SIRS) or sepsis, and even death. 1, 4, 5 Citrulline (CIT), a nonprotein amino acid, is involved in arginine (ARG) and nitric oxide (NO) metabolism and the urea cycle. 6, 7 Synthesized from glutamine primarily in the small intestine, CIT is released from enterocytes into blood. 8, 9 For this reason, since the early 2000s, .....
Document: primarily in the small bowel include diarrhea, dehydration, malnutrition, potentially systemic inflammatory response syndrome (SIRS) or sepsis, and even death. 1, 4, 5 Citrulline (CIT), a nonprotein amino acid, is involved in arginine (ARG) and nitric oxide (NO) metabolism and the urea cycle. 6, 7 Synthesized from glutamine primarily in the small intestine, CIT is released from enterocytes into blood. 8, 9 For this reason, since the early 2000s, plasma CIT concentration has been used as a biomarker for enterocyte mass and absorptive function in various intestinal diseases [10] [11] [12] [13] [14] [15] and sepsis 16, 17 in humans, independent of nutritional and inflammatory status. 18 Therefore, it could be useful to predict the health and function of the intestine in calves. NO is known to have various physiological functions, including neurotransmission, immune defense, and organ perfusion and play a key role in various pathological processes.
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