Selected article for: "cleaved expression and emodin induce"
Author: Dong, Xiaoxv; Ni, Boran; Fu, Jing; Yin, Xingbin; You, Longtai; Leng, Xin; Liang, Xiao; Ni, Jian
Title: Emodin induces apoptosis in human hepatocellular carcinoma HepaRG cells via the mitochondrial caspase-dependent pathway
  • Document date: 2018_8_2
    • ID: 02r8i5n1_29
    Snippet: Apoptosis initiated by increased ROS production after emodin treatment might induce apoptosis-related protein change. Compared with the control cells, our data suggested that the treatment of HepaRG cells with emodin significantly increased the protein expression levels of p53, p21, Bax, cleaved caspases-3, and -9 and PARP, while emodin decreased Bcl-2 levels. Furthermore, emodin promoted cytochrome c release from mitochondria into the cytosol. P.....
    Document: Apoptosis initiated by increased ROS production after emodin treatment might induce apoptosis-related protein change. Compared with the control cells, our data suggested that the treatment of HepaRG cells with emodin significantly increased the protein expression levels of p53, p21, Bax, cleaved caspases-3, and -9 and PARP, while emodin decreased Bcl-2 levels. Furthermore, emodin promoted cytochrome c release from mitochondria into the cytosol. Previous studies have shown that emodin induced apoptosis in cancer cells through the mitochondrial-dependent apoptotic pathway (47) (48) (49) , which was consistent with our experiments. In addition, emodin induced hepatocellular carcinoma cell apoptosis through the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/AKT signaling pathways (15, 50) .

    Search related documents:
    Co phrase search for related documents
    • apoptotic pathway and cancer cell apoptosis: 1
    • apoptotic pathway and carcinoma cell: 1, 2, 3
    • apoptotic pathway and carcinoma cell apoptosis: 1
    • apoptotic pathway and control cell: 1
    • apoptotic pathway and expression level: 1, 2
    • cancer cell and carcinoma cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • cancer cell and carcinoma cell apoptosis: 1, 2
    • cancer cell and control cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • cancer cell and expression level: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • cancer cell apoptosis and carcinoma cell: 1, 2
    • cancer cell apoptosis and carcinoma cell apoptosis: 1, 2
    • cancer cell apoptosis and control cell: 1
    • cancer cell apoptosis and expression level: 1, 2, 3
    • carcinoma cell and control cell: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • carcinoma cell and expression level: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • carcinoma cell apoptosis and expression level: 1
    • control cell and expression level: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12