Author: Tingting Li; Qingbing Zheng; Hai Yu; Dinghui Wu; Wenhui Xue; Yuyun Zhang; Xiaofen Huang; Lizhi Zhou; Zhigang Zhang; Zhenghui Zha; Tingting Chen; Zhiping Wang; Jie Chen; Hui Sun; Tingting Deng; Yingbin Wang; Yixin Chen; Qinjian Zhao; Jun Zhang; Ying Gu; Shaowei Li; Ningshao Xia
Title: Characterization of the SARS-CoV-2 Spike in an Early Prefusion Conformation Document date: 2020_3_17
ID: i9r77o70_9
Snippet: The SARS-CoV-2 spike expressed in insect cells predominantly retains a unique 298 early prefusion conformation, which was repeatable in at least three batches of samples 299 and is ascribed to two possible reasons -native aa sequence used in the S ectodomain The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.16.994152 doi: bioRxiv preprint first Ni-NAT and the second SEC purification (Fig.....
Document: The SARS-CoV-2 spike expressed in insect cells predominantly retains a unique 298 early prefusion conformation, which was repeatable in at least three batches of samples 299 and is ascribed to two possible reasons -native aa sequence used in the S ectodomain The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.16.994152 doi: bioRxiv preprint first Ni-NAT and the second SEC purification (Fig. 1C and 1E ). Further analyses 303 suggest the split between S1 and S2 likely takes no effect on the trimerization of S Various versions of S proteins are the major targets for vaccine immunogen candidate.
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