Author: Zhengqiao Zhao; Bahrad A. Sokhansanj; Gail L. Rosen
Title: Characterizing geographical and temporal dynamics of novel coronavirus SARS-CoV-2 using informative subtype markers Document date: 2020_4_9
ID: 9sk11214_40
Snippet: Interestingly, cluster C (purple) with putative endogenous U.S. subtypes is closer to the cluster with 520 predominantly cases from Asia than cluster A (colored green), which ontains subtypes first seen in Europe, 521 including the subtype that is dominant in New York state (TTTCGTCCACGTGTGGG). Overall, ISM clustering 522 further supports the hypothesis that the emergent putative endogenous U.S. subtypes is linked to the original 523 U.S. outbrea.....
Document: Interestingly, cluster C (purple) with putative endogenous U.S. subtypes is closer to the cluster with 520 predominantly cases from Asia than cluster A (colored green), which ontains subtypes first seen in Europe, 521 including the subtype that is dominant in New York state (TTTCGTCCACGTGTGGG). Overall, ISM clustering 522 further supports the hypothesis that the emergent putative endogenous U.S. subtypes is linked to the original 523 U.S. outbreaks linked to Asia, and that subtypes in the New York outbreak are conversely linked more 524 directly to Europe. We are currently following up on the proof-of-concept clustering results shown here to 525 develop more sophisticated machine learning approaches to identify patterns in viral subtype distribution.
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