Author: Sabath, Niv; Wagner, Andreas; Karlin, David
Title: Evolution of Viral Proteins Originated De Novo by Overprinting Document date: 2012_7_19
ID: 629fwmgk_12
Snippet: We first compared these three properties for all ancestral/ de novo gene pairs. Table 2 summarizes the results of this comparison. Overall, de novo genes evolve significantly faster (paired two-sided Wilcoxon signed rank test, P< 7.1 Â 10 À34 ), are under stronger selective constraint (P < 2.9 Â 10 À4 ), and exhibit lower CSI values (P < 5.4 Â 10 À5 ) than ancestral genes. The magnitude of the difference between the mean CSI of ancestral ge.....
Document: We first compared these three properties for all ancestral/ de novo gene pairs. Table 2 summarizes the results of this comparison. Overall, de novo genes evolve significantly faster (paired two-sided Wilcoxon signed rank test, P< 7.1 Â 10 À34 ), are under stronger selective constraint (P < 2.9 Â 10 À4 ), and exhibit lower CSI values (P < 5.4 Â 10 À5 ) than ancestral genes. The magnitude of the difference between the mean CSI of ancestral genes (0.66) and that of de novo genes (0.62) is low (6%), whereas the difference between the mean relative divergence of the ancestral and de novo genes is high (43%), as is the difference between the selection intensity of ancestral and de novo genes (47%).
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