Author: Sabath, Niv; Wagner, Andreas; Karlin, David
Title: Evolution of Viral Proteins Originated De Novo by Overprinting Document date: 2012_7_19
ID: 629fwmgk_18
Snippet: Overall, we found that the differences between ancestral and de novo genes appears to decrease with time. Taxa 1-5, with the shortest distance from the origin-corresponding to the youngest de novo genes-all exhibit a similar pattern ( fig. 3) : the de novo genes show higher relative divergence with respect to their ancestral overlapping genes and weaker selective constraint. The pattern that contrasts most with that of taxa 1-5 occurs in taxa 7 a.....
Document: Overall, we found that the differences between ancestral and de novo genes appears to decrease with time. Taxa 1-5, with the shortest distance from the origin-corresponding to the youngest de novo genes-all exhibit a similar pattern ( fig. 3) : the de novo genes show higher relative divergence with respect to their ancestral overlapping genes and weaker selective constraint. The pattern that contrasts most with that of taxa 1-5 occurs in taxa 7 and 12 (Ilarvirus and Betanodavirus, respectively), where the de novo genes have a more ancient origin. Here, the de novo genes evolve more slowly and exhibit stronger purifying selection relative to their ancestral overlapping genes ( fig. 3) . In other words, here mutations that change the sequence of the de novo proteins are more deleterious, on average, than mutations that change the sequence of the overlapping ancestral proteins.
Search related documents:
Co phrase search for related documents- ancestral overlap gene and de novo gene: 1
- ancestral overlap gene and overlap gene: 1, 2
- ancestral overlap gene and purifying selection: 1
- ancestral overlap gene and slowly evolve: 1
- ancestral protein and de novo ancestral gene: 1, 2
- ancestral protein and de novo gene: 1, 2, 3, 4
- ancestral protein and de novo protein: 1, 2, 3
- ancestral protein and overlap gene: 1, 2
- ancestral protein and purifying selection: 1, 2, 3
- ancestral protein and relative divergence: 1, 2
- ancestral protein and selective constraint: 1, 2
- ancestral protein and slowly evolve: 1
- ancestral protein and strong purifying selection: 1
- ancient origin and de novo gene: 1
- ancient origin and purifying selection: 1
- de novo ancestral gene and high relative divergence: 1
- de novo ancestral gene and overlap gene: 1
- de novo ancestral gene and purifying selection: 1
- de novo ancestral gene and relative divergence: 1, 2, 3
Co phrase search for related documents, hyperlinks ordered by date