Author: Fausther-Bovendo, Hugues; Kobinger, Gary P
Title: Pre-existing immunity against Ad vectors: Humoral, cellular, and innate response, what's important? Document date: 2014_11_1
ID: 3894l9qi_24
Snippet: Tremendous effort has been made in circumventing pre-existing Ad immunity in the human population. An important focus Figure 3 . Model of tissue resident T cells induction by various vaccination routes. The majority of vector and insert specific tissue resident T cells will reside close to the site of immunization, in the tissue where the antigen was first encountered. Some of these resident T cells migrate away from the injection site while rema.....
Document: Tremendous effort has been made in circumventing pre-existing Ad immunity in the human population. An important focus Figure 3 . Model of tissue resident T cells induction by various vaccination routes. The majority of vector and insert specific tissue resident T cells will reside close to the site of immunization, in the tissue where the antigen was first encountered. Some of these resident T cells migrate away from the injection site while remaining within the same tissue. Depending on the immunization routes, the generated tissue resident T cells will reside in different tissues. Of note, circulating T cells are not depicted.
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