Author: Riede, O; Seifert, K; Oswald, D; Endmann, A; Hock, C; Winkler, A; Salguero, F J; Schroff, M; Croft, S L; Juhls, C
Title: Preclinical safety and tolerability of a repeatedly administered human leishmaniasis DNA vaccine Document date: 2015_4_30
ID: 4eyn7pjq_19
Snippet: Notably, MIDGE-Th1 vector DNA did not accumulate in any tissue after repeated injections. At 60 days after one injection 21 or after four injections of LEISHDNAVAX, comparable amounts of MIDGE-Th1 vector DNA were found, indicating that repeated injections do not enhance persistence. Therefore, future evaluations of biodistribution and persistence of MIDGE-Th1 vectors in similar settings can be based on a single injection......
Document: Notably, MIDGE-Th1 vector DNA did not accumulate in any tissue after repeated injections. At 60 days after one injection 21 or after four injections of LEISHDNAVAX, comparable amounts of MIDGE-Th1 vector DNA were found, indicating that repeated injections do not enhance persistence. Therefore, future evaluations of biodistribution and persistence of MIDGE-Th1 vectors in similar settings can be based on a single injection.
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