Author: Riede, O; Seifert, K; Oswald, D; Endmann, A; Hock, C; Winkler, A; Salguero, F J; Schroff, M; Croft, S L; Juhls, C
Title: Preclinical safety and tolerability of a repeatedly administered human leishmaniasis DNA vaccine Document date: 2015_4_30
ID: 4eyn7pjq_29
Snippet: Animals were observed for clinical signs including injection site reactogenicity before and 30 min and 4 h after each dosing and daily between injections. Mortality was evaluated twice daily throughout the study. Body weight of animals was recorded at day of group allocation, on the day of first dosing and three times a week thereafter. Food consumption was determined weekly and water consumption was recorded daily. Neurological screening 40 and .....
Document: Animals were observed for clinical signs including injection site reactogenicity before and 30 min and 4 h after each dosing and daily between injections. Mortality was evaluated twice daily throughout the study. Body weight of animals was recorded at day of group allocation, on the day of first dosing and three times a week thereafter. Food consumption was determined weekly and water consumption was recorded daily. Neurological screening 40 and assessment of grip strength 41 was conducted on all animals 24 h after first dosing. Ophthalmological and auditory examinations were performed pre-dose, at the end of the treatment period and at the end of the recovery period.
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