Selected article for: "housekeeping gene and relative gene"
Author: Sabath, Niv; Wagner, Andreas; Karlin, David
Title: Evolution of Viral Proteins Originated De Novo by Overprinting
  • Document date: 2012_7_19
    • ID: 629fwmgk_34
    Snippet: One important caveat of our analysis is that we are unable to estimate the absolute age of de novo genes but only their age relative to the divergence of a viral housekeeping gene that encodes the RNA-dependent RNA polymerase. Our relative age estimates of de novo genes, however, are broadly consistent with their taxonomic distribution (table 1, column 6): as expected, young de novo genes show a more restricted distribution than older de novo gen.....
    Document: One important caveat of our analysis is that we are unable to estimate the absolute age of de novo genes but only their age relative to the divergence of a viral housekeeping gene that encodes the RNA-dependent RNA polymerase. Our relative age estimates of de novo genes, however, are broadly consistent with their taxonomic distribution (table 1, column 6): as expected, young de novo genes show a more restricted distribution than older de novo genes. The youngest genes (groups 1-3 in fig. 3 ) are found in less than one genus, with gene 1 occurring only in a single species (these observations are not due to sequencing bias, as each taxon considered contains several species or genera). Conversely, all oldest de novo genes (6-12) are found at least throughout a whole genus (in two genera for cases 10 and 11).

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