Author: Sabath, Niv; Wagner, Andreas; Karlin, David
Title: Evolution of Viral Proteins Originated De Novo by Overprinting Document date: 2012_7_19
ID: 629fwmgk_5
Snippet: Taking the above considerations into account, we ask the following questions about the evolutionary dynamics of de novo genes: Do de novo genes adapt to their genome, and if so, how rapidly? What is their rate of evolution? How do the de novo genes influence the genes that they overlap? Do de novo genes contribute to viral fitness? To answer these questions, we analyzed the evolution of 12 independent, experimentally validated de novo genes in RN.....
Document: Taking the above considerations into account, we ask the following questions about the evolutionary dynamics of de novo genes: Do de novo genes adapt to their genome, and if so, how rapidly? What is their rate of evolution? How do the de novo genes influence the genes that they overlap? Do de novo genes contribute to viral fitness? To answer these questions, we analyzed the evolution of 12 independent, experimentally validated de novo genes in RNA viruses. We estimated their relative age and compared their evolutionary dynamics to that of the ancestral gene from which they originated.
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