Author: Kim, Sung-Kwon; Cornberg, Markus; Wang, Xiaoting Z.; Chen, Hong D.; Selin, Liisa K.; Welsh, Raymond M.
Title: Private specificities of CD8 T cell responses control patterns of heterologous immunity Document date: 2005_2_21
ID: 55gi6gyx_25
Snippet: which the randomness in the heterologous T cell response could be addressed. CFSE-labeled LCMV-immune donor cells derived from a single donor were transferred into multiple hosts, which were infected with VV ( Fig. 3 A) . We reasoned that if the secondary response on VV challenge was random, variable epitope patterns would be observed among the different recipients of LCMV-immune cells derived from the same donor. If the putatively cross-reactive.....
Document: which the randomness in the heterologous T cell response could be addressed. CFSE-labeled LCMV-immune donor cells derived from a single donor were transferred into multiple hosts, which were infected with VV ( Fig. 3 A) . We reasoned that if the secondary response on VV challenge was random, variable epitope patterns would be observed among the different recipients of LCMV-immune cells derived from the same donor. If the putatively cross-reactive epitope-specific expansions were similar between recipients, this would argue against randomness and would strengthen the argument that the unique, or private, epitope-specific repertoire of the donor determines the pattern of heterologous immunity.
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