Author: Kim, Sung-Kwon; Cornberg, Markus; Wang, Xiaoting Z.; Chen, Hong D.; Selin, Liisa K.; Welsh, Raymond M.
Title: Private specificities of CD8 T cell responses control patterns of heterologous immunity Document date: 2005_2_21
ID: 55gi6gyx_31
Snippet: Proliferation and private specificities of LCMV-immune donor-derived A11R 198-specific CD8 T cells upon VV infection were confirmed via adoptive transfer experiments with CFSE-labeled cells (Fig. 4 C) . Here, the day 6 response to A11R 198 is compared with the nearly always poor GP276 response. Donors A and C gave rise to a proliferative A11R 198 response in each of their recipients, whereas Donor B gave rise to no A11R response in either recipie.....
Document: Proliferation and private specificities of LCMV-immune donor-derived A11R 198-specific CD8 T cells upon VV infection were confirmed via adoptive transfer experiments with CFSE-labeled cells (Fig. 4 C) . Here, the day 6 response to A11R 198 is compared with the nearly always poor GP276 response. Donors A and C gave rise to a proliferative A11R 198 response in each of their recipients, whereas Donor B gave rise to no A11R response in either recipient. This documents the private specificities in challenge virusencoded epitope-specific T cell responses that can be engendered as a consequence of heterologous immunity to a previously encountered virus.
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